Potential associations between variants of genes encoding regulators of inflammation, and mediators of inflammation in type 2 diabetes and insulin resistance.
Cansu ÖzbayerMedine Nur KebapciHulyam KurtErtugrul ColakHasan Veysi GunesIrfan DegirmenciPublished in: Journal of clinical pharmacy and therapeutics (2021)
Our results show that high COX-2 and iNOS levels are associated with T2DM, besides MyD88, IRAK4 and TRAF6 gene variations may not be closely related to type 2 diabetes and insulin resistance. Nevertheless, studies in this pathway with a different population and a large number of patients are important.
Keyphrases
- type diabetes
- insulin resistance
- glycemic control
- end stage renal disease
- oxidative stress
- metabolic syndrome
- adipose tissue
- high fat diet
- copy number
- ejection fraction
- cardiovascular disease
- chronic kidney disease
- polycystic ovary syndrome
- genome wide
- skeletal muscle
- newly diagnosed
- high fat diet induced
- peritoneal dialysis
- prognostic factors
- toll like receptor
- nitric oxide
- transcription factor
- gene expression
- inflammatory response
- risk assessment
- human health
- nitric oxide synthase
- climate change
- dna methylation
- weight loss
- bioinformatics analysis