Peptidylarginine Deiminase Autoimmunity and the Development of Anti-Citrullinated Protein Antibody in Rheumatoid Arthritis: The Hapten-Carrier Model.
Isabelle AugerNathalie BalandraudEmmanuel MassyMarie F HemonElisa PeenFanny ArnouxCharlotte MariotMarielle MartinPierre LafforgueJean-Marc BusnelJean RoudierPublished in: Arthritis & rheumatology (Hoboken, N.J.) (2020)
ACPA immunity is associated with antibodies to PAD4 and T cell responses to PAD4 and PAD4 peptides. These findings are consistent with a hapten-carrier model in which PAD4 is the carrier and citrullinated proteins are the haptens.