Unexpected inflammation in the sympathetic ganglia in thromboangiitis obliterans: more likely sterile or infectious induced inflammation?
Behzad MousazadehHiva SharebianiHossein TaheriNarges ValizedehBahare FazeliPublished in: Clinical and molecular allergy : CMA (2019)
It appears that the inflammation in the SG of TAO patients is more likely a sterile inflammation, and its trigger may be mitochondrial DNA (mtDNA). Cadmium in cigarettes could be responsible for the induction of mtDNA release to the cell cytoplasm. In addition, the high expression of HMGB1 may play a role in the pathogenesis of TAO and may be responsible for both clinical manifestation of the disease and the imaging findings. Moreover, HMGB1 may be a target for treatment protocols for TAO. Further studies are highly recommended.
Keyphrases
- mitochondrial dna
- oxidative stress
- copy number
- end stage renal disease
- diabetic rats
- chronic kidney disease
- newly diagnosed
- high resolution
- ejection fraction
- prognostic factors
- cell therapy
- smoking cessation
- dna methylation
- high glucose
- drug induced
- gene expression
- replacement therapy
- peritoneal dialysis
- bone marrow
- fluorescence imaging