Growth Hormone-Releasing Hormone Receptor Antagonist Modulates Lung Inflammation and Fibrosis due to Bleomycin.

Chongxu ZhangRenzhi CaiAaron LazersonGaetan DelcroixMedhi WangpaichitrMehdi MirsaeidiAnthony J GriswoldAndrew V SchallyRobert M Jackson

Published in: Lung (2019)

MIA-602 reduced lung inflammation and fibrosis due to bleomycin. Multiple genes related to immune response and T-cell functions were downregulated, supporting the view that MIA-602 can modulate the cellular immune response to bleomycin lung injury.

Keyphrases

pulmonary fibrosis
growth hormone
immune response
oxidative stress
genome wide
bioinformatics analysis
drug induced
genome wide analysis