A new diketopiperazine-like inhibitor of bone morphogenetic protein-induced osteoblastic differentiation produced by marine-derived Aspergillus sp. BFM-0085.
Satoshi OhteTakehiro ShiokawaNobuhiro KoyamaTakenobu KatagiriChiaki ImadaHiroshi TomodaPublished in: The Journal of antibiotics (2020)
A new diketopiperazine-like compound, designated protuboxepin K (1), was isolated together with the known structurally related protuboxepin A (2) from culture broth of the marine-derived fungal strain Aspergillus sp. BFM-0085 isolated from a sediment sample of Tokyo Bay. The structure of protuboxepin K was elucidated by spectroscopic data, including 1D and 2D NMR. Compounds 1 and 2 inhibited bone morphogenetic protein (BMP)-induced alkaline phosphatase activity with IC50 values of 4.7 and 25.2 μM, respectively, in mutant BMP receptor-carrying C2C12(R206H) cells.
Keyphrases
- high glucose
- diabetic rats
- mesenchymal stem cells
- induced apoptosis
- drug induced
- magnetic resonance
- cell wall
- molecular docking
- oxidative stress
- electronic health record
- endothelial cells
- big data
- risk assessment
- cell death
- machine learning
- cell proliferation
- mass spectrometry
- endoplasmic reticulum stress
- vascular smooth muscle cells
- stress induced
- signaling pathway
- binding protein
- angiotensin ii
- solid state