Dysregulation of LINC00324 associated with methylation facilitates leukemogenesis in de novo acute myeloid leukemia.
Guo-Kang SunZi-Jun XuFang-Yu NanLi-Juan TangDong-Ming YaoPublished in: International journal of laboratory hematology (2022)
Our findings firstly identified that the hypomethylation of LINC00324 was a common molecular event in de novo AML patients. The abnormally upregulated LINC00324 promotes proliferation and inhibits apoptosis in leukemia cells.
Keyphrases
- acute myeloid leukemia
- long non coding rna
- long noncoding rna
- cell cycle arrest
- cell proliferation
- end stage renal disease
- induced apoptosis
- ejection fraction
- allogeneic hematopoietic stem cell transplantation
- chronic kidney disease
- oxidative stress
- signaling pathway
- bone marrow
- prognostic factors
- genome wide
- dna methylation