Chromium-Catalyzed Three-Component Synthesis of Monofluoroalkenes from gem -Difluoroalkenes via C-O/C-H and C-F Bond Activation.

Published in: Organic letters (2023)

We report here the chromium-catalyzed three-component defluorinative cross-couplings of gem -difluoroalkenes with benzyl 2-pyridinyl ethers and aryl Grignard reagents under mild conditions, enabling the convenient synthesis of diarylmethylated monofluoroalkenes in good chemo- and stereoselectivity.

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