Detection of retinal and blood Aβ oligomers with nanobodies.
Umma HabibaJoseph DescallarFabian KreilausUtpal K AdhikariSachin KumarJohn W MorleyBang V BuiMaya K HamaouiMourad TayebiPublished in: Alzheimer's & dementia (Amsterdam, Netherlands) (2021)
These results suggest that retinal accumulation of Aβo originates from peripheral blood and precedes cognitive decline and Aβo deposition in the brain. This provides a very strong basis to develop and implement an "eye test" for early detection of AD using nanobodies targeting retinal Aβ.