Anti-tumor activity of cediranib, a pan-vascular endothelial growth factor receptor inhibitor, in pancreatic ductal adenocarcinoma cells.

Majid MomenyZivar AlishahiHaniyeh EyvaniFatemeh EsmaeiliAzam ZaghalParisa GhaffariJavad Tavakkoly-BazzazKamran AlimoghaddamArdeshir GhavamzadehSeyed H Ghaffari

Published in: Cellular oncology (Dordrecht) (2019)

Our data indicate that cediranib may exhibit anti-tumor activity in PDAC cells and provide a rationale for further investigation of the potential of VEGF receptor-targeted therapies for the treatment of PDAC.

Keyphrases

vascular endothelial growth factor
induced apoptosis
cell cycle arrest
endothelial cells
pi k akt