Sleep and Chronobiology as a Key to Understand Cluster Headache.
Laura PilatiAngelo TorrentePaolo AlongeLavinia VassalloSimona MaccoraAndrea GagliardoAntonia PignoloSalvatore IaconoSalvatore FerlisiVincenzo Di StefanoCecilia CamardaFilippo BrighinaPublished in: Neurology international (2023)
The cluster headache is a primary headache characterized by attacks of unilateral pain associated with ipsilateral cranial autonomic features. These attacks recur in clusters during the years alternating with periods of complete remission, and their onset is often during the night. This annual and nocturnal periodicity hides a strong and mysterious link among CH, sleep, chronobiology and circadian rhythm. Behind this relationship, there may be the influence of genetic components or of anatomical structures such as the hypothalamus, which are both involved in regulating the biological clock and contributing even to the periodicity of cluster headaches. The bidirectional relationship manifests itself also with the presence of sleep disturbances in patients affected by cluster headaches. What if the key to studying the physiopathology of such disease could rely on the mechanisms of chronobiology? The purpose of this review is to analyze this link in order to interpret the pathophysiology of cluster headaches and the possible therapeutic implications.
Keyphrases
- sleep quality
- end stage renal disease
- physical activity
- newly diagnosed
- ejection fraction
- blood pressure
- heart rate
- gene expression
- obstructive sleep apnea
- chronic kidney disease
- neuropathic pain
- patient reported outcomes
- copy number
- pain management
- spinal cord
- mass spectrometry
- depressive symptoms
- peritoneal dialysis
- rheumatoid arthritis
- room temperature
- heart rate variability
- ulcerative colitis