Mitochondrial haplogroup G is associated with nonalcoholic fatty liver disease, while haplogroup A mitigates the effects of PNPLA3.

Aaron M GusdonYou HuiJing ChenClayton E MathewsShen Qu

Published in: Endocrinology, diabetes & metabolism (2020)

Haplogroup G was associated with an increased risk of NAFLD PNPLA3 GG genotype was overrepresented among patients encoding haplogroup A and was not associated with NAFLD risk among haplogroup A patients. Mitochondrial genetics influence NAFLD risk and interact with PNPLA3 genotypes.

Keyphrases

mitochondrial dna
copy number
end stage renal disease
oxidative stress
ejection fraction
newly diagnosed
chronic kidney disease
peritoneal dialysis
prognostic factors
genome wide
patient reported outcomes
gene expression
radiation therapy