Interplay between the genetics of personality traits, severe psychiatric disorders and COVID-19 host genetics in the susceptibility to SARS-CoV-2 infection.
Urs HeilbronnerFabian StreitThomas VoglFanny SennerSabrina K SchauppDaniela Reich-ErkelenzSergi PapiolMojtaba Oraki KohshourFarahnaz Klöhn-SaghatolislamJanos L KalmanMaria HeilbronnerKathrin GadeAshley L ComesMonika BuddeTill F M AndlauerHeike Anderson-SchmidtKristina AdorjanTil StürmerAdrian LoerbroksManfred AmelangEric PoiselJerome FooStefanie Heilmann-HeimbachAndreas J ForstnerFranziska DegenhardtJörg ZimmermannJens WiltfangMartin von HagenCarsten SpitzerMax SchmaussEva ReininghausJens ReimerCarsten KonradGeorg JuckelFabian U LangMarkus JägerChristian FiggeAndreas J FallgatterDetlef E DietrichUdo DannlowskiBernhardt T BauneVolker AroltIon-George AnghelescuMarkus M NöthenStephanie H WittOle A AndreassenChi-Hua ChenPeter FalkaiMarcella RietschelThomas G SchulzeEva C SchultePublished in: BJPsych open (2021)
We identified no significant correlation between genetic risk factors for severe psychiatric disorders and genetic risk for COVID-19 susceptibility. Among the personality traits, extraversion showed evidence for a positive genetic association with COVID-19 susceptibility, in one but not in another setting. Overall, these findings highlight a complex contribution of genetic and non-genetic components in the interaction between COVID-19 susceptibility and personality traits or mental disorders.