Serum Biomarker Profiles Discriminate AQP4 Seropositive and Double Seronegative Neuromyelitis Optica Spectrum Disorder.

Sara CartaAlessandro Dinoto Marco Alfonso CapobiancoPaola ValentinoFrancesca MontaroloArianna Sala Markus ReindlMarianna Lo ReVanessa ChiodegaPierre BrangerBertrand AudoinJennifer AboabCaroline PapeixNicolas CollonguesPhilippe KerschenHelene Zephir Alain Créange Bertrand BourreKathrin SchandaEoin Patrick FlanaganVyanka RedenbaughJavier Villacieros-Álvarez Georgina Arrambide Álvaro Cobo-CalvoSergio FerrariRomain MarignierSara Mariotto

Published in: Neurology(R) neuroimmunology & neuroinflammation (2023)

Serum GFAP, tau, and UCH-L1 levels discriminate between AQP4+NMOSD and DS-NMOSD. The different biomarker profile of AQP4+NMOSD vs DS-NMOSD suggests heterogeneity of diseases within the latter category and provides useful data to improve our understanding of this disease.

Keyphrases

spectrum disorder
single cell
electronic health record
machine learning
cerebrospinal fluid
deep learning