A HIV-1 Gp41 Peptide-Liposome Vaccine Elicits Neutralizing Epitope-Targeted Antibody Responses in Healthy Individuals.
Nathan B ErdmannWilton B WilliamsStephen R WalshNicole GrunenbergPaul T EdlefsenPaul A GoepfertDerek W CainKristen W CohenJanine MaenzaKenneth H MayerHong Van TieuMagdalena E SobieszczykEdith SwannHuiyin LuStephen C De RosaZachary SagawaM Anthony MoodyChristopher B FoxGuido FerrariR J EdwardsPriyamvada AcharyaS Munir AlamRobert ParksMargaret BarrGeorgia D TomarasDavid C MontefioriPeter B GilbertM Juliana McElrathLawrence CoreyBarton F HaynesLindsey R Badennull nullPublished in: medRxiv : the preprint server for health sciences (2024)
MPER-peptide liposomes induced gp41 serum neutralizing epitope-targeted antibodies and memory B-cell responses in humans despite the early termination of the study. These results suggest that the MPER region is a promising target for a candidate HIV vaccine.