Honokiol, an inducer of Sirtuin 3, protects against NSAID-induced gastric mucosal mitochondrial pathology, apoptosis and inflammatory tissue injury.

Subhashis DebsharmaSaikat PramanikSamik BinduSomnath MazumderTroyee DasDebanjan SahaRudranil DeShiladitya NagChinmoy BanerjeeAsim Azhar SiddiquiZhumur GhoshUday Bandyopadhyay

Published in: British journal of pharmacology (2023)

Sirtuin-3 stimulation by HKL prevented as well as restored NSAID-induced gastric injury through maintaining mitochondrial integrity. HKL did not affect gastric acid secretion. Sirtuin-3 stimulation by HKL may be capitalized as a mitochondria-based, acid-independent novel gastroprotective strategy against NSAIDs.

Keyphrases

oxidative stress
diabetic rats
high glucose
cell death
drug induced
endoplasmic reticulum stress
signaling pathway
reactive oxygen species
cell cycle arrest
ulcerative colitis
endoplasmic reticulum