Honokiol, an inducer of Sirtuin 3, protects against NSAID-induced gastric mucosal mitochondrial pathology, apoptosis and inflammatory tissue injury.
Subhashis DebsharmaSaikat PramanikSamik BinduSomnath MazumderTroyee DasDebanjan SahaRudranil DeShiladitya NagChinmoy BanerjeeAsim Azhar SiddiquiZhumur GhoshUday BandyopadhyayPublished in: British journal of pharmacology (2023)
Sirtuin-3 stimulation by HKL prevented as well as restored NSAID-induced gastric injury through maintaining mitochondrial integrity. HKL did not affect gastric acid secretion. Sirtuin-3 stimulation by HKL may be capitalized as a mitochondria-based, acid-independent novel gastroprotective strategy against NSAIDs.