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Honokiol, an inducer of Sirtuin 3, protects against NSAID-induced gastric mucosal mitochondrial pathology, apoptosis and inflammatory tissue injury.

Subhashis DebsharmaSaikat PramanikSamik BinduSomnath MazumderTroyee DasDebanjan SahaRudranil DeShiladitya NagChinmoy BanerjeeAsim Azhar SiddiquiZhumur GhoshUday Bandyopadhyay
Published in: British journal of pharmacology (2023)
Sirtuin-3 stimulation by HKL prevented as well as restored NSAID-induced gastric injury through maintaining mitochondrial integrity. HKL did not affect gastric acid secretion. Sirtuin-3 stimulation by HKL may be capitalized as a mitochondria-based, acid-independent novel gastroprotective strategy against NSAIDs.
Keyphrases
  • oxidative stress
  • diabetic rats
  • high glucose
  • cell death
  • drug induced
  • endoplasmic reticulum stress
  • signaling pathway
  • reactive oxygen species
  • cell cycle arrest
  • ulcerative colitis
  • endoplasmic reticulum