Multimodal neuroimaging markers of variation in cognitive ability in older HIV+ men.
Ana Lucia Fernandez CruzChien-Ming ChenRyan SanfordD Louis CollinsMarie-Josée BrouilletteNancy E MayoLesley K FellowsPublished in: PloS one (2021)
This is the first study to use task-evoked EEG to identify neural correlates of individual differences in cognition in men living with well-controlled HIV infection, and to explore the structural basis of the EEG markers. We found that EEG responses evoked by the oddball task are more reliably related to cognitive performance than those evoked by the Simon task. We also provide preliminary evidence for a subcortical contribution to the effects of HIV infection severity on P300 amplitudes. These results suggest brain mechanisms and candidate biomarkers for individual differences in cognition in HIV.
Keyphrases
- antiretroviral therapy
- resting state
- functional connectivity
- hiv infected
- white matter
- hiv positive
- human immunodeficiency virus
- structural basis
- hiv aids
- working memory
- middle aged
- hiv testing
- hepatitis c virus
- mild cognitive impairment
- men who have sex with men
- multiple sclerosis
- community dwelling
- south africa
- high density
- subarachnoid hemorrhage