Budesonide and N-acetylcysteine inhibit activation of the NLRP3 inflammasome by regulating miR-381 to alleviate acute lung injury caused by the pyroptosis-mediated inflammatory response.
Rongfang ZhangAiping YangJin FuLi ZhangLiyue YinTing XuChunhui DaiWenbing SuWanling ShenPublished in: Toxicology research (2024)
Overall, this study revealed that BUN + NAC inhibits the activation of NLRP3 by regulating miR-381, thereby alleviating ALI caused by pyroptosis-mediated inflammation.