Increase of liver stiffness and altered bile acid metabolism after triple CFTR modulator initiation in children and young adults with cystic fibrosis.

Alexander SchnellJörg JüngertDaniel KlettHannah HoberNatalie KaiserRenate RuppelAnnika GeppertChristina TremelJulia SobelErika PlattnerSabina Schmitt-GrohéSabine ZirlikDeike StrobelMarkus F NeurathFerdinand KnielingManfred RauhJoachim WoelfleAndré HoerningAdrian P Regensburger

Published in: Liver international : official journal of the International Association for the Study of the Liver (2023)

ARFI SWV and bile acid profiles provide evidence for early increase of liver stiffness and altered bile acid metabolism in young CF patients after initiation of ETI and may serve as synergistic measures for detection of hepatic complications during ETI therapy.

Keyphrases

young adults
cystic fibrosis
end stage renal disease
chronic kidney disease
prognostic factors
drug delivery
cancer therapy
cell therapy
patient reported
quantum dots
chemotherapy induced