Genome-wide association study implicates novel loci and reveals candidate effector genes for longitudinal pediatric bone accrual.
Diana L CousminerYadav WagleyJames A PippinAhmed ElhakeemGregory P WayMatthew C PahlShana E McCormackAlessandra ChesiJonathan A MitchellJoseph M KindlerDenis BairdApril HartleyLaura HoweHeidi J KalkwarfJoan M LappeSumei LuMichelle E LeonardMatthew E JohnsonHakon HakonarsonVicente GilsanzJohn A ShepherdSharon E OberfieldCasey S GreeneAndrea KellyDeborah A LawlorBenjamin F VoightAndrew D WellsBabette S ZemelKurt D HankensonStruan F A GrantPublished in: Genome biology (2021)
Using a new longitudinal approach, we expand the number of genetic loci putatively associated with pediatric bone gain. Functional follow-up in appropriate cell models finds novel candidate genes impacting bone accrual. Our data also raise the possibility that the cell fate decision between osteogenic and adipogenic lineages is important in normal bone accrual.
Keyphrases
- genome wide association study
- bone mineral density
- genome wide
- soft tissue
- bone loss
- bone regeneration
- cell fate
- postmenopausal women
- mesenchymal stem cells
- electronic health record
- dna methylation
- dendritic cells
- gene expression
- immune response
- big data
- decision making
- genome wide association
- bioinformatics analysis