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An early look at selective RET inhibitor resistance: new challenges and opportunities.

Jessica J LinJustin F Gainor
Published in: British journal of cancer (2021)
Two RET inhibitors, selpercatinib and pralsetinib, recently received approval for the treatment of advanced RET fusion-positive lung cancer. Acquired resistance to these inhibitors will be a major challenge. We have shown that resistance can emerge due to recurrent RET kinase domain mutations and, in most cases, due to RET-independent mechanisms.
Keyphrases
  • drug administration