Patterns of failure after radiation therapy in primary spinal high-grade gliomas: A single institutional analysis.
Rituraj UpadhyaySwapnil KhoseHalyna PokhylevychArnold C PaulinoMary Frances McAleerAmol GhiaJing LiDebra Nana YeboaMonica LoghinRebecca HarrisonBarbara O'BrienCarlos Kamiya-MatsuokaJohn De GrootVinay K PuduvalliClaudio TatsuiChristopher Alvarez-BreckenridgeSujit PrabhuLarry RhinesWafik ZakyFrank LinJeffery S WeinbergGregory FullerDavid I SandbergJason Michael JohnsonSusan Lynne McGovernPublished in: Neuro-oncology advances (2022)
The prognosis of patients with spinal HGGs remains poor with two-thirds of the patients developing distant recurrence despite chemoradiation. Survival outcomes were similar in patients ≤ 29 years compared to adults > 29 years. A better understanding of the molecular drivers of spinal HGGs is needed to develop more effective treatment options.