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Cord blood DNA methylome in newborns later diagnosed with autism spectrum disorder reflects early dysregulation of neurodevelopmental and X-linked genes.

Charles E MordauntJulia M JianuBenjamin I LauferYihui ZhuHyeyeon HwangKeith W DunawayKelly M BakulskiJason I FeinbergHeather E VolkKristen LyallLisa A CroenCraig J NewschafferSally OzonoffIrva Hertz-PicciottoM Daniele FallinRebecca J SchmidtJanine M LaSalle
Published in: Genome medicine (2020)
At birth, prior to the diagnosis of ASD, a distinct DNA methylation signature was detected in cord blood over regulatory regions and genes relevant to early fetal neurodevelopment. Differential cord methylation in ASD supports the developmental and sex-biased etiology of ASD and provides novel insights for early diagnosis and therapy.
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