Role of Piezo2 in Schwann Cell Volume Regulation and Its Impact on Neurotrophic Release Regulation.
Chawapun SuttinontKatsuyuki MaenoMamiko YanoKaori Sato-NumataTomohiro NumataMoe TsutsumiPublished in: Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology (2024)
Our study unveils the mechanosensitivity of SCs and implicates Piezo2 channels in the release of neurotrophic factors from SCs. These results suggest that Piezo2 may contribute to RVD, thereby maintaining cellular homeostasis, and may also serve as a negative regulator of neurotrophic factor release. These findings underscore the need for further investigation into the role of Piezo2 in SC function and neurotrophic regulation.
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