Digital breast tomosynthesis in mammographic screening: false negative cancer cases in the To-Be 1 trial.
Nataliia MoshinaAxel GräwingholtKristina LångRitse MannTone HovdaSolveig Roth HoffPer SkaaneChristoph I LeeHildegunn S AaseAslak B AslaksenSolveig HofvindPublished in: Insights into imaging (2024)
• Screening with digital breast tomosynthesis (DBT) did not result in a higher breast cancer detection rate compared to screening with digital mammography (DM) in the To-Be 1 trial. • The false negative rates for examinations prior to interval and consecutive screen-detected cancer for DBT were determined in the trial to test if the lack of differences was due to interpretive error. • The false negative rates were consistent with those of prior DM reviews, indicating that the lack of higher cancer detection for DBT versus DM was complex and not due to interpretive error alone.