The role of chromosomal microarray analysis among fetuses with normal karyotype and single system anomaly or nonspecific sonographic findings.

Shuk Yi Annie Hui Matthew Hoi Kin ChauYiu Man ChanYe CaoAngel Hw KwanXiaofan ZhuYvonne K KwokZihan ChenTerence T LaoKwong-Wai Choy Tak Yeung Leung

Published in: Acta obstetricia et gynecologica Scandinavica (2020)

The diagnostic yield of chromosomal microarray in fetuses with normal karyotype and ultrasound abnormality confined to a single anatomic system was highest if it involved cardiac defects or intrauterine growth restriction. This diagnostic yield ranges from 0% to 4.6% depending on the anatomic system involved. Chromosomal microarray has considerable diagnostic value in these pregnancies.

Keyphrases

gestational age
copy number
magnetic resonance imaging
preterm birth
left ventricular
heart failure
bioinformatics analysis
gene expression
ultrasound guided