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Violaceous nodules of the extensor joints - a clinicopathological challenge.

Daniel R AntohiDonald LeiMichael OccidentalBijal AminJeanie LeeShudan WangBenedict Wu
Published in: International journal of dermatology (2024)
Antineutrophilic cytoplasmic antibody (ANCA)-associated vasculitis (AAV) is a condition characterized by vessel inflammation and may have a variety of etiologies. Among these, cocaine and its common adulterant, levamisole, have been described to contribute to the development of AAV with distinct cutaneous manifestations. Classically, these manifestations involve purpuric or necrotic lesions involving the ears, nose, and extremities. However, we present a case of cocaine-induced AAV presenting with violaceous nodules on the dorsal hands in order to demonstrate that this condition may not always present with retiform purpura and skin necrosis.
Keyphrases
  • gene therapy
  • soft tissue
  • oxidative stress
  • diabetic rats
  • spinal cord
  • high glucose
  • neuropathic pain
  • drug induced
  • endothelial cells