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High Levels of Circulating Tumor Plasma Cells as a Key Hallmark of Aggressive Disease in Transplant-Eligible Patients With Newly Diagnosed Multiple Myeloma.

Luca BertaminiStefania OlivaDelia Rota-ScalabriniLaura ParisSonia MorèPaolo CorradiniAntonio LeddaMassimo GentileGiovanni De SabbataGiuseppe PietrantuonoAnna PascarellaPatrizia TosiPaola CurciMilena GilestroAndrea CapraPiero GalieniFrancesco PisaniOmbretta AnnibaliFederico MonacoAnna Marina LiberatiSalvatore PalmieriMario LuppiRenato ZambelloFrancesca FazioAngelo BelottiPaola TacchettiPellegrino MustoMario BoccadoroFrancesca Gay
Published in: Journal of clinical oncology : official journal of the American Society of Clinical Oncology (2022)
In multiple myeloma, increasing levels of CTC above an optimal cutoff represent an easy-to-assess, robust, and independent high-risk factor. The achievement of MRD negativity is the most important factor that modulates their negative prognostic impact.
Keyphrases
  • multiple myeloma
  • circulating tumor
  • newly diagnosed
  • circulating tumor cells
  • induced apoptosis
  • cell free
  • risk factors
  • cell cycle arrest
  • endoplasmic reticulum stress
  • oxidative stress
  • cell proliferation