Endoplasmic reticulum stress promotes the release of exosomal PD-L1 from head and neck cancer cells and facilitates M2 macrophage polarization.

Yi YuanPengfei JiaoZeyu WangMengqi ChenHongming DuLiang XuJuanyong XuYoujin DaiFu-Gen WuYaqin ZhangHeming Wu

Published in: Cell communication and signaling : CCS (2022)

ER stress causes OSCC cells to secrete exosomal PD-L1 and upregulates PD-L1 expression in macrophages to drive M2 macrophage polarization. The delineation of a new exosome-modulated mechanism was made for OSCC-macrophage crosstalk driving tumor development and to be examined for its therapeutic use. Exosomal PD-L1 secreted by ER-stressed OSCC cells promoted M2 macrophage polarization. Video Abstract.

Keyphrases

induced apoptosis
endoplasmic reticulum stress
cell cycle arrest
signaling pathway
oxidative stress
adipose tissue
cell death
cell proliferation