N 6 -methyladenosine-modified circSTX6 promotes hepatocellular carcinoma progression by regulating the HNRNPD/ATF3 axis and encoding a 144 amino acid polypeptide.

Jiahua LuJunnan RuYunhao ChenZhenan LingHanqing LiuBo DingYifan JiangJun MaDeguo ZhangJiangzhen GeYu LiFei SunDiyu ChenShushen ZhenJian Wu

Published in: Clinical and translational medicine (2023)

A-modified circSTX6 drives malignancy in HCC through the HNRNPD/ATF3 axis, while its encoded circSTX6-144aa contributes to HCC progression independent of circSTX6. CirSTX6 and its encoded protein hold promise as potential biomarkers and therapeutic targets in HCC.

Keyphrases

amino acid
transcription factor
endoplasmic reticulum stress
protein protein
binding protein