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Coadministration of tizanidine and ciprofloxacin: a retrospective analysis of the WHO pharmacovigilance database.

Annette RudolphHendrike DahmkeHugo KupferschmidtAndrea BurdenStefan Weiler
Published in: European journal of clinical pharmacology (2021)
Despite the existing formal contraindication, the concomitant use of tizanidine and ciprofloxacin can be observed in real-world clinical practice. Reactions mainly affected the central nervous and the cardiovascular system resulting in potentially severe adverse effects. The concomitant use of tizanidine and ciprofloxacin should absolutely be avoided.
Keyphrases
  • pseudomonas aeruginosa
  • clinical practice
  • adverse drug
  • cystic fibrosis
  • emergency department