Coadministration of tizanidine and ciprofloxacin: a retrospective analysis of the WHO pharmacovigilance database.
Annette RudolphHendrike DahmkeHugo KupferschmidtAndrea BurdenStefan WeilerPublished in: European journal of clinical pharmacology (2021)
Despite the existing formal contraindication, the concomitant use of tizanidine and ciprofloxacin can be observed in real-world clinical practice. Reactions mainly affected the central nervous and the cardiovascular system resulting in potentially severe adverse effects. The concomitant use of tizanidine and ciprofloxacin should absolutely be avoided.