Bisoprolol and linagliptin ameliorated electrical and mechanical isometric myocardial contractions in doxorubicin-induced cardiomyopathy in rats.

Duygun Altıntaş AykanSelma YamanNadire EserTuba Özcan MetinMuhammed SeyithanoğluAhmet Çağrı AykanAkif Hakan KurtYusuf Ergün

Published in: Pharmacological reports : PR (2019)

Doxorubicin resulted in pronounced oxidative stress. The beneficial effects of bisoprolol and linagliptin on myocardial functional, histopathological and biochemical changes could be related to the attenuation of oxidative load.

Keyphrases

oxidative stress
diabetic rats
left ventricular
drug delivery
cancer therapy
high glucose
heart failure
dna damage
resistance training
induced apoptosis
endothelial cells
atrial fibrillation
endoplasmic reticulum stress
high intensity