The chromatin remodeling subunit Baf200 promotes normal hematopoiesis and inhibits leukemogenesis.

Lulu LiuXiaoling WanPeipei ZhouXiaoyuan ZhouWei ZhangXinhui HuiXiujie YuanXiaodan DingRuihong ZhuGuangxun MengHui XiaoFeng MaHe HuangXianmin SongBin ZhouSidong XiongYan Zhang

Published in: Journal of hematology & oncology (2018)

Our current studies uncover critical roles of Baf200 in both normal and malignant hematopoiesis and provide a potential therapeutic target for suppressing the progression of leukemia without interfering with normal hematopoiesis.

Keyphrases

gene expression
dna damage
acute myeloid leukemia
bone marrow
transcription factor
genome wide
risk assessment
oxidative stress
climate change
protein kinase