NOL4 is Downregulated and Hyper-Methylated in Papillary Thyroid Carcinoma Suggesting Its Role as a Tumor Suppressor Gene.

Sara SheikholeslamiFereidoun AziziAsghar GhasemiAbbas AlibakhshiHossein ParsaSeyed Mohammad TavangarSetareh ShivaeeMarjan Zarif YeganehMehdi HedayatiLadan Teimoori-Toolabi

Published in: International journal of endocrinology and metabolism (2020)

These data suggested an aberrant promoter hyper-methylation of NOL4 in PTC cases may be linked with its downregulation. Therefore, NOL4 gene can be proposed as a potential tumor suppressor gene in PTC tissues.

Keyphrases

genome wide
copy number
dna methylation
genome wide identification
gene expression
transcription factor
cell proliferation
lymph node metastasis
squamous cell carcinoma
signaling pathway
electronic health record
big data
artificial intelligence
genome wide analysis
human health