Divergent effects of exendin-4 and interleukin-6 on rat colonic secretory and contractile activity are associated with changes in regional vagal afferent signaling.

Rebecca O'BrienMaria M Buckley Dervla O'Malley

Published in: Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society (2021)

Application of Ex-4 in the presence of IL-6 had divergent modulatory effects on colonic secretion and contractile activity. Similar patterns were observed in vagal afferent signaling originating in the submucosal and myenteric neuronal layers, indicating regional afferent activity reflected immune- and endocrine-mediated changes in colonic function.

Keyphrases

skeletal muscle
ulcerative colitis
oxidative stress
brain injury
solar cells