CLEAR: coverage-based limiting-cell experiment analysis for RNA-seq.
Logan A WalkerMichael G SovicChi-Ling ChiangEileen HuJiyeon K DenningerXi ChenElizabeth D KirbyJohn C ByrdNatarajan MuthusamyRalf BundschuhPearlly S YanPublished in: Journal of translational medicine (2020)
lcRNA-seq coupled with CLEAR is widely used in our institution for profiling immune cells (circulating or tissue-infiltrating) for its transcript preservation characteristics. CLEAR fills an important niche in pre-processing lcRNA-seq data to facilitate transcriptome profiling and DEG analysis. We demonstrate the utility of CLEAR in analyzing rare cell populations in clinical samples and in murine neural DG region without sample pooling.