Genetic variants demonstrating flip-flop phenomenon and breast cancer risk prediction among women of African ancestry.

Shengfeng WangFrank QianYonglan ZhengTemidayo OgundiranOladosu OjengbedeWei ZhengWilliam BlotKatherine L NathansonAnselm HennisBarbara NemesureStefan AmbsOlufunmilayo I OlopadeDezheng Huo

Published in: Breast cancer research and treatment (2018)

We found that PRS based on variants identified from prior GWASs conducted in women of European and Asian ancestries did not provide a comparable degree of risk stratification for women of African ancestry. Further large-scale fine-mapping studies in African ancestry populations are desirable to discover population-specific genetic risk variants.

Keyphrases

polycystic ovary syndrome
breast cancer risk
copy number
pregnancy outcomes
cervical cancer screening
air pollution
high resolution
insulin resistance
genome wide association study
gene expression
adipose tissue
case control