The hepato-ovarian axis: genetic evidence for a causal association between non-alcoholic fatty liver disease and polycystic ovary syndrome.

Dong LiuXue GaoXiong-Fei PanTao ZhouCairong ZhuFei LiJian-Gao FanGiovanni TargherJian Zhao

Published in: BMC medicine (2023)

Our study suggests that genetically predicted NAFLD was associated with a higher risk of developing PCOS but less evidence for vice versa. Fasting insulin and sex hormones might mediate the link between NAFLD and PCOS.

Keyphrases

polycystic ovary syndrome
insulin resistance
type diabetes
adipose tissue
skeletal muscle
genome wide
copy number
gene expression
blood pressure