Inadequate anticoagulation and hyperuricemia cause knee pain after platelet-rich plasma injection: A retrospective study.
Yang ChenHongxun SangSong WuHaobin ZhangYi ZhangHongxing LiPublished in: Journal of orthopaedic surgery (Hong Kong) (2024)
The results suggest that platelet-rich plasma prepared using high-dose anticoagulants or administered to patients with poorly controlled hyperuricaemia may lead to moderate-to-severe knee pain and joint effusion after joint puncture therapy. Platelet-rich plasma had a therapeutic effect on knee osteoarthritis; however, its efficacy gradually decreased over time. SC anticoagulant is more suitable for platelet-rich plasma preparation than is heparin. Further studies are needed to understand the safety and the various factors influencing platelet-rich plasma therapy.
Keyphrases
- platelet rich plasma
- knee osteoarthritis
- high dose
- venous thromboembolism
- chronic pain
- total knee arthroplasty
- pain management
- atrial fibrillation
- neuropathic pain
- stem cells
- early onset
- high resolution
- high intensity
- metabolic syndrome
- growth factor
- anterior cruciate ligament reconstruction
- cell therapy
- smoking cessation