NFkappaB is a Key Player in the Crosstalk between Inflammation and Cardiovascular Diseases.
Antonella FiordelisiGuido IaccarinoCarmine MoriscoEnrico CoscioniDaniela SorrientoPublished in: International journal of molecular sciences (2019)
Inflammation is a key mechanism of cardiovascular diseases. It is an essential component of atherosclerosis and a significant risk factor for the development of cardiovascular events. In the crosstalk between inflammation and cardiovascular diseases, the transcription factor NFκB seems to be a key player since it is involved in the development and progression of both inflammation and cardiac and vascular damage. In this review, we deal with the recent findings of the role of inflammation in cardiac diseases, focusing, in particular, on NFκB as a functional link. We describe strategies for the therapeutic targeting of NFκB as a potential strategy for the failing heart.
Keyphrases
- oxidative stress
- cardiovascular disease
- cardiovascular events
- signaling pathway
- transcription factor
- lps induced
- coronary artery disease
- heart failure
- pi k akt
- drug delivery
- inflammatory response
- atrial fibrillation
- cardiovascular risk factors
- climate change
- cell proliferation
- cancer therapy
- dna binding
- human health