Effects of Developmental Lead and Phthalate Exposures on DNA Methylation in Adult Mouse Blood, Brain, and Liver: A Focus on Genomic Imprinting by Tissue and Sex.
Rachel K MorganKai WangLaurie K SvobodaChristine A RygielClaudia LalancetteRaymond CavalcanteMarisa S BartolomeiRexxi PrasasyaKari NeierBambarendage P U PereraTamara R JonesJustin A ColacinoMaureen A SartorDana C DolinoyPublished in: Environmental health perspectives (2024)
These data provide preliminary evidence that imprinted genes may be viable candidates in the search for epigenetic biomarkers of toxicant exposure in target tissues. Additional research is needed on allele- and developmental stage-specific effects, as well as whether other imprinted genes provide additional examples of this relationship. https://doi.org/10.1289/EHP14074.
Keyphrases
- dna methylation
- genome wide
- gene expression
- copy number
- genome wide identification
- bioinformatics analysis
- air pollution
- white matter
- electronic health record
- solid phase extraction
- genome wide analysis
- multiple sclerosis
- transcription factor
- mass spectrometry
- artificial intelligence
- blood brain barrier
- deep learning
- young adults
- simultaneous determination