Impact of Whole Genome Doubling on Detection of Circulating Tumor DNA in Colorectal Cancer.
Jonas KabelTenna Vesterman HenriksenChristina DemuthAmanda FrydendahlMads Heilskov RasmussenJesper NorsNicolai Juul BirkbakAnders Husted MadsenUffe Schou LøvePer Vadgaard AndersenThomas KolbroAlessio MontiOle Thorlacius-UssingMikail GögenurJeppe KildsigNis Hallundbæk SchlesingerPeter BondevenLene Hjerrild IversenKåre Andersson GotschalckClaus Lindbjerg AndersenPublished in: Cancers (2023)
The presence of WGD significantly increases the probability of detecting ctDNA, particularly for early-stage disease. In patients with more advanced disease, the benefit of WGD on ctDNA detection is less pronounced, consistent with increased DNA shedding from these tumors, making ctDNA detection less dependent on the amount of ctDNA released per tumor cell.