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Chromoanasynthesis is a common mechanism that leads to ERBB2 amplifications in a cohort of early stage HER2+ breast cancer samples.

George VasmatzisXue WangJames B SmadbeckStephen J MurphyKatherine B GeiersbachSarah H JohnsonAthanasios G GaitatzesYan W AsmannFarhad KosariMitesh J BoradDaniel J SerieSarah A McLaughlinJennifer M KachergusBrian M NecelaE Aubrey Thompson
Published in: BMC cancer (2018)
Chromoanasynthesis involving chromosome 17 can lead to ERBB2 amplifications in HER2+ breast cancer. However, additional large genomic alterations contribute to a high level of genomic complexity, generating the hypothesis that worse outcome could be associated with multiple chromoanasynthetic events.
Keyphrases
  • early stage
  • copy number
  • tyrosine kinase
  • radiation therapy
  • dna methylation
  • young adults
  • breast cancer risk