Chromoanasynthesis is a common mechanism that leads to ERBB2 amplifications in a cohort of early stage HER2+ breast cancer samples.
George VasmatzisXue WangJames B SmadbeckStephen J MurphyKatherine B GeiersbachSarah H JohnsonAthanasios G GaitatzesYan W AsmannFarhad KosariMitesh J BoradDaniel J SerieSarah A McLaughlinJennifer M KachergusBrian M NecelaE Aubrey ThompsonPublished in: BMC cancer (2018)
Chromoanasynthesis involving chromosome 17 can lead to ERBB2 amplifications in HER2+ breast cancer. However, additional large genomic alterations contribute to a high level of genomic complexity, generating the hypothesis that worse outcome could be associated with multiple chromoanasynthetic events.