The neurodevelopmental transcriptome of the Drosophila melanogaster microcephaly gene abnormal spindle reveals a role for temporal transcription factors and the immune system in regulating brain size.

Maria C ManninoMercedes Bartels CassidySteven FlorezZeid RusanShalini ChakrabortyTodd A Schoborg

Published in: bioRxiv : the preprint server for biology (2023)

mutants. Our results add to the growing number of pathways necessary for brain growth control, and provide a suitable foundation for follow-up genetic studies to assess MCPH.

Keyphrases

drosophila melanogaster
genome wide
resting state
white matter
transcription factor
copy number
zika virus
functional connectivity
cerebral ischemia
intellectual disability
dna methylation
single cell
multiple sclerosis
autism spectrum disorder
congenital heart disease
dna binding