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An engineered cell sheet composed of human islets and human fibroblast, bone marrow-derived mesenchymal stem cells, or adipose-derived mesenchymal stem cells: An in vitro comparison study.

Hajime ImamuraTomohiko AdachiTatsuya KinShinichiro OnoYusuke SakaiToshiyuki AdachiAkihiko SoyamaMasaaki HidakaMitsuhisa TakatsukiA M James ShapiroSusumu Eguchi
Published in: Islets (2018)
Engineered cell sheets composed of islets and supporting cells had a cytoprotective effect on islets. These results suggest that individual cell types could be a more attractive source for crafting engineered cell sheets in comparison to islets alone.
Keyphrases
  • single cell
  • bone marrow
  • cell therapy
  • endothelial cells
  • stem cells
  • type diabetes
  • adipose tissue
  • oxidative stress
  • skeletal muscle
  • cell cycle arrest
  • pi k akt