An engineered cell sheet composed of human islets and human fibroblast, bone marrow-derived mesenchymal stem cells, or adipose-derived mesenchymal stem cells: An in vitro comparison study.
Hajime ImamuraTomohiko AdachiTatsuya KinShinichiro OnoYusuke SakaiToshiyuki AdachiAkihiko SoyamaMasaaki HidakaMitsuhisa TakatsukiA M James ShapiroSusumu EguchiPublished in: Islets (2018)
Engineered cell sheets composed of islets and supporting cells had a cytoprotective effect on islets. These results suggest that individual cell types could be a more attractive source for crafting engineered cell sheets in comparison to islets alone.