Conjugated and Entrapped HPMA-PLA Nano-Polymeric Micelles Based Dual Delivery of First Line Anti TB Drugs: Improved and Safe Drug Delivery against Sensitive and Resistant Mycobacterium Tuberculosis.

Seema UpadhyayIliyas KhanAvinash GothwalPraveen K PachouriN BhaskarUmesh D GuptaDevendra S ChauhanUmesh Gupta

Published in: Pharmaceutical research (2017)

RIF loaded and INH conjugated HPMA-PLA polymeric micelles (PMRI) were more effective against sensitive and resistant M tuberculosis. The developed approach can lead to improved patient compliance and reduced dosing in future, offering improved treatment of tuberculosis.

Keyphrases

drug delivery
mycobacterium tuberculosis
pulmonary tuberculosis
cancer therapy
drug release
photodynamic therapy
hiv aids
emergency department
current status
combination therapy
human immunodeficiency virus
hiv infected
drug induced