Biochemical Profiling of Urine Metabolome in Premature Infants Based on LC-MS Considering Maternal Influence.
Jeong-Hun MokJoon-Hwan SongWon-Ho HahnSeonghyeon ChoJong-Moon ParkJiwon KohHo KimNam Mi KangPublished in: Nutrients (2024)
In this study, Liquid Chromatography-Mass Spectrometry (LC-MS)-based metabolomics profiling was conducted to elucidate the urinary profiles of premature infants during early and late postnatal stages. As a result, we discovered significant excretion of maternal drugs in early-stage infants and identified crucial metabolites like hormones and amino acids. These findings shed light on the maternal impact on neonatal metabolism and underscore the beneficial effects of breastfeeding on the metabolism of essential amino acids in infants. This research not only enhances our understanding of maternal-infant nutritional interactions and their long-term implications for preterm infants but also offers critical insights into the biochemical characteristics and physiological mechanisms of preterm infants, laying a groundwork for future clinical studies focused on neonatal development and health.
Keyphrases
- preterm infants
- mass spectrometry
- liquid chromatography
- birth weight
- low birth weight
- amino acid
- early stage
- pregnancy outcomes
- public health
- healthcare
- high resolution
- high resolution mass spectrometry
- gestational age
- capillary electrophoresis
- radiation therapy
- tandem mass spectrometry
- health information
- gas chromatography
- risk assessment
- climate change
- preterm birth
- physical activity
- health promotion
- genome wide analysis
- locally advanced