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Cluster of pregnancy-associated melanoma: A case report and brief update.

Nicholas Van RooijAgnieszka AdamsBrian De'AmbrosisVaishnavi NathanNicholas HaywardDavid C Whiteman
Published in: The Journal of dermatology (2020)
Melanoma incidence is increasing globally with Australia having the highest incidence in the world. Pregnancy-associated melanoma is recognized in the published work; however, significant knowledge deficiencies exist. We present the case of a 34-year-old woman with dysplastic nevus syndrome who over a 15-year period developed a total of nine melanomas, with eight clustered around an 18-month peri- to post-partum period. The first eight lesions were in situ with the ninth lesion invasive. No metastatic disease was observed over the 18-year follow-up period. This case identifies the potential sensitivity of a subset of melanomas to pregnancy-related factors, with particular relevance to the development of lesions in the post-partum period. We suggest that patients with a history of any documented melanoma risk factors, particularly dysplastic nevus syndrome, require close monitoring especially during pregnancy and early post-partum.
Keyphrases
  • risk factors
  • skin cancer
  • preterm birth
  • pregnancy outcomes
  • healthcare
  • small cell lung cancer
  • squamous cell carcinoma
  • case report
  • basal cell carcinoma
  • gene expression
  • pregnant women
  • systematic review