Asymmetric Transfer Hydrogenation of gem -Difluorocyclopropenyl Ketones: The Synthesis and Functionalization of Enantioenriched cis gem -Difluorocyclopropyl Ketones.
Olivier CharronMarharyta KosiuhaPhannarath PhansavathVirginie Ratovelomanana-VidalGeoffrey GontardChristophe MeyerPublished in: The Journal of organic chemistry (2024)
The asymmetric transfer hydrogenation of gem -difluorocyclopropenyl ketones, catalyzed by a Noyori-Ikariya ruthenium complex, was developed to access substituted optically enriched cis -disubstituted gem -difluorocyclopropyl ketones, and the value of these latter building blocks was illustrated by the synthesis of heterocycles fused to the difluorocyclopropyl moiety.
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