Escherichia coli O8:H8 Carrying a Novel Variant of the Heat-Labile Enterotoxin LT2 Gene Caused Outbreaks of Diarrhea.
Kai IshimaruMari SasakiHiroshi NarimatsuYoko ArimizuYasuhiro GotohKeiji NakamuraTetsuya HayashiYoshitoshi OguraPublished in: Open forum infectious diseases (2020)
No outbreaks caused by Escherichia coli-producing heat-labile enterotoxin LT2 have been reported to date. Here, we revealed that the E. coli O8:H8 strains isolated from patients in 2 independent diarrhea outbreaks were negative for any known virulence determinants in routine microbiological tests, were very closely related, and carried a prophage-encoded gene for a novel LT2 variant (LT2d) and the genes for colonization factor antigen III. We also showed that LT2d has a cytotonic activity similar to LT1. These data indicate the importance of E. coli strains producing LT2d as a human pathogen.
Keyphrases
- escherichia coli
- genome wide
- biofilm formation
- end stage renal disease
- klebsiella pneumoniae
- ejection fraction
- newly diagnosed
- copy number
- peritoneal dialysis
- heat stress
- machine learning
- pseudomonas aeruginosa
- clostridium difficile
- staphylococcus aureus
- cystic fibrosis
- big data
- dna methylation
- gene expression
- multidrug resistant
- single cell
- deep learning
- genome wide analysis
- patient reported outcomes
- antimicrobial resistance