TRPV4 is expressed by enteric glia and muscularis macrophages of the colon but does not play a prominent role in colonic motility.
Pradeep RajasekharSimona E CarboneStuart T JohnstonCameron J NowellLukasz WiklendtEdmund J CrampinYinghan SheJesse J DiCelloAyame SaitoLuke SorensenThanh NguyenKevin Mc LeeJohn A HamiltonSebastian K KingEmily M ErikssonNick J SpencerBrian D GulbransenNicholas A VeldhuisDaniel P PoolePublished in: bioRxiv : the preprint server for biology (2024)
We reveal a previously unappreciated role for TRPV4 in the initiation of distension-evoked colonic motility. These observations provide new insights into the functional role of TRPV4 activation in the gut, with important implications for how TRPV4 may influence critical processes including inflammatory signaling and motility.